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However, repressive chromatin marks and the recruitment of silencing protein complexes were found in the non-expressing hypermethylated RAJI and MEG-01 cell lines, again validating the interrelationship between DNA methylation and histone marks (Karius et al., 2011)

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In some cases we have been able to give causal explanations for observed experimental phenomena and we are able to test the quantitative effects of various allosteric inhibitions and excitations

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For example, if you're not pregnant, a significant change in weight can cause a delay in periods

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